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Omega 3 and Prostate Health

Higher Blood Levels of Long-chain Omega-3 Fatty Acids and Linoleic Acid are Associated with a Reduced Risk of Prostate Cancer

In a prospective, nested, case-control study involving 14,916 apparently healthy men, results indicate that higher blood levels of both long-chain omega-3 fatty acids and linoleic acid may be associated with a reduced risk of prostate cancer. During 13 years of follow-up, 476 men were diagnosed with prostate cancer. Using conditional logistic regression, inverse associations were observed between whole blood levels of all long-chain omega-3 fatty acids and linoleic acid and overall prostate cancer risk. The highest quintile for blood levels of total long-chain omega-3 fatty acids was associated with a 41% reduced risk of overall prostate cancer. Similarly, the highest quintile for blood levels of linoleic acid was associated with a 38% reduced risk of overall prostate cancer. On the other hand, a positive association was observed between blood levels of gamma-linolenic and dihomo-gamma-linolenic acids with overall prostate cancer risk. Thus, the authors of this study conclude, "Higher blood levels of long-chain omega-3 fatty acids, mainly found in marine foods, and of linoleic acid, mainly found in non-hydrogenated vegetable oils, are associated with a reduced risk of prostate cancer. The direct associations of linoleic acid metabolites with prostate cancer risk deserve further investigation."

Reference: "A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk," Chavarro JE, Stampfer MJ, et al, Cancer Epidemiol Biomarkers Prev, 2007 June 21; [Epub ahead of print]. (Address: Jorge E. Chavarro, Dep't of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. E-mail: jchavarr@hsph.harvard.edu ).

 


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