|
Andropause is associated with low ("bioavailable") testosterone levels.
Every man experiences a decline of bioavailable testosterone but some men's
levels dip lower than others. And when this happens these men can experience
Andropausal symptoms.

These symptoms can impact their quality of life and may expose them to
other, longer-term risks of low testosterone. It is estimated that 30% of men in
their 50s will have testosterone levels low enough to be causing symptoms or
putting them at risk.
Why is testosterone so important?
Testosterone is a hormone that has a unique
effect on a man's total body. It is produced in the testes and in the adrenal
glands. It is to males what estrogen is to females. Testosterone helps to build
protein and is essential for normal sexual behavior and producing erections. It
also affects many metabolic activities such as production of blood cells in the
bone marrow, bone formation, lipid meta-bolism, carbohydrate metabolism, liver
function and prostate gland growth.

Impact of low bioavailable testosterone
When there is less testosterone available to do its work, the testosterone
target organ response decreases, bringing about many changes. There is great
variability in testosterone levels among healthy men so not all will experience
the same changes to the same extent. But typical responses to low bioavailable
testosterone levels include:
- Low sex drive
- Emotional, psychological and behavioral changes
- Decreased muscle mass
- Loss of muscle strength
- Increased upper and central body fat
Is Andropause a new phenomenon?
Yes and no. In fact, Andropause was first described in medical literature in
the 1940's. So it's not really new. But, our ability to diagnose it properly is.
Sensitive tests for bioavailable testosterone weren't available until recently,
so Andropause has gone through a long period where it was under-diagnosed and
under-treatare living longer, there is heightened interest in Andropause and
this will help to advance our approach to this important life stage which was
identified so long ago.
Diagnosing Andropause
Another reason why Andropause has been under-diagnosed over the years is
that symptoms can be vague and can vary a lot among individuals. Some men find
it difficult to admit that there's even a problem. And often physicians didn't
always think of low testosterone levels as a possible culprit. So these factors
often lead doctors to conclude that symptoms were related to other medical
conditions (i.e. depression) or were simply related to aging and often
encouraged their patients to accept that "they were no longer spring chickens".
But this situation is changing. New blood testing methods are available and
there is a increased interest in men's' aging among medical researchers. In
fact, so much attention is being focused on Andropause that major efforts are
underway to quickly share emerging scientific information with Canadian
physicians.
Am I going through Andropause?
Take this test and take the first step to
feeling better.
1. Do you have a decrease in your sex drive (libido)?
YES
NO
2. Do you have a lack of energy?
YES
NO
3. Do you have a decrease in strength and/or endurance?
YES
NO
4. Have you lost height?
YES
NO
5. Have you noticed a decreased "enjoyment in life"?
YES
NO
6. Are you sad and/or grumpy?
YES
NO
7. Are your erections less strong?
YES
NO
8. Have you noticed a recent deterioration in your ability to play sports?
YES
NO
9. Are you falling asleep after dinner?
YES
NO
10. Has there been a recent deterioration in your work performance?
YES
NO
Of course, every person is different. And not all men going through this
stage of life will experience it exactly the same way. The passage into middle
age is a complicated phase. It's full of changes at all levels - personal,
social, economic, family, etc. It may therefore be difficult to differentiate
these changes from the symptoms of other conditions that can create some of the
same symptoms.
Nevertheless, if you did answer "Yes" to 1 or 7 or to any three questions
in all, it would be worthwhile discussing these symptoms with your physician.
He/she may then have your bioavailable testosterone level checked.
Why should Andropause be taken seriously?
Apart from the impact that Andropause may have on your quality of life,
there are other longer-term and silent effects of Andropause that are harder to
track: increased cardiovascular risk and osteoporosis.
Andropause & Osteoporosis
In a healthy
individual, bone tissue is constantly being broken down and rebuilt. In an
individual with osteoporosis, more bone tissue is lost than is regenerated.
We've all heard of women suffering from weaker bones, or osteoporosis, after
menopause. In men, testosterone is thought to play a role in helping to maintain
this balance. Between the ages of 40 and 70 years, male bone density falls by up
to 15 percent.

Unfortunately, with advancing age and declining testosterone levels, men
seem to demonstrate a similar pattern of risk for osteoporosis as women. What's
more, approximately one in eight men over age 50 actually has osteoporosis. The
incidence of hip fractures rises exponentially in aging men, as it does in
women, starting about 5 to 10 years later than in women. In Canada, 20-30% of
osteoporotic fractures occur in men. The incidence in fractures has been
increasing in men, whereas it seems to be stabilizing in women Ñ likely due to
the lifestyle changes, calcium supplements and hormone replacement therapies
that women are embracing.
Why should I worry about osteoporosis?
Low bone density puts one at risk of frequent fractures, associated pain,
and in many cases, loss of independence. Wrists, hips, spine and ribs are most
commonly affected. The consequences of osteoporosis are often seen as a slow but
progressive rounding of the shoulders and loss of height. Particularly
devastating seem to be hip fractures - up to one third of patients never seem to
regain full mobility.
Cardiovascular risks *
It is now well accepted that women's risk of atherosclerosis (hardening of
the arteries) increases after menopause. Estrogen replacement therapy seems to
reverse this trend. New evidence suggests that a similar phenomenon occurs in
men as their testosterone levels diminish with age. While research is not as
complete as for women, the clinical findings point to an association between low
testosterone levels and an increase in cardiovascular risk factors in men.
* A cause and effect relationship has not
yet been established in large clinical trials. The current clinical work does
support further research into this important area of study.
What can you do about Andropause?
1. Understand your own risks for osteoporosis.
It is impossible to predict who will get osteoporosis. However, there are
several factors that can put certain men at increased risk. These include:
- Age
- Low testosterone levels
- Family history of osteoporosis
- Thin and/or small frame
- Use of certain medications such as corticosteroids, anticonvulsants and
anti-rejection drugs
- Excessive alcohol consumption
- Smoking
- Lack of weight-bearing exercise
If you have any of these risk factors you may want to find out more about
osteoporosis prevention from your physician or from other providers of
information on osteoporosis.
2. Talk to your physician about the role
testosterone replacement therapy can play.
Just as with estrogen replacement therapy in women with menopause,
testosterone replacement in men with Andropause has been shown to be highly
effective and very beneficial. Its not for every man, of course, even men who
have the symptoms on the previous quiz may have other health problems at the
root of it all. Testosterone replacement therapy is a good solution for many men
who are experiencing symptoms that are having an affect on their enjoyment of
life.
Your doctor will check carefully to see if you are a suitable candidate,
including performing blood tests and physical examinations. Importantly, if you
have an established prostate tumor or have breast cancer you will not be a
candidate for testosterone replacement therapy. If you are a candidate for
testosterone replacement therapy the options include oral capsules, injections
and skin patches. Expect your physician to monitor your progress and your
overall health while on testosterone treatment. If you're like the majority of
men, you will experience very few side effects, if any.
3. Maintain a healthy lifestyle.
Of course, any ongoing strategy to reduce the symptoms and risks of
Andropause should incorporate lifestyle approaches such as optimal diet, regular
exercise, stress-management, and the reduction in tobacco and alcohol intake.
What should I expect from testosterone replacement?
Very good responses to testosterone have been reported for men with low
testosterone in various clinical studies and they include:
- Improvement in mood and sense of well-being
- Increased mental and physical energy
- Decreased anger, irritability, sadness, tiredness, nervousness
- Improved quality of sleep
- Improved libido and sexual performance
- A decline in biochemical markers of bone degradation and an increase in
bone density
- An increase in lean body mass, a decline in fat mass
- An increase in muscle strength (hand grip, upper and lower
extremities).
- Potentially, a decrease in the risk of heart disease
With testosterone therapy, one's attitude improves, reinforcing
self-esteem and self-confidence in success at work, and increased energy at home
and in social activities. Most men will feel more vigorous, experience
improvement in energy levels, mood, concentration, cognition, libido, sexual
performance and overall sense of well-being. This effect is usually noted in 3
to 6 weeks. Other potential benefits include maintenance or improvement in bone
density, improved body composition, muscle mass and muscle strength, as well as
improvement in visual-spatial skills.
Questions and Answers
- Q: Does Viagra have the same actions as
testosterone?
A: It is testosterone that is the normal
basis of sexual desire in both men and women. So if it is low, so is the desire
for sex. Viagra is not a testosterone replacement therapy and it is prescribed
to help maintain erections. It does not treat the whole man. Other symptoms such
as reduced mental and physical energy, irritability and sweating may also impact
your sex life. And these symptoms may also be caused by a decline in your
testosterone level. So talk to your doctor about choosing the strategy that's
right for you to improve your sexual well-being.
- Q: am already taking so many
medications for this and that. Should I learn to age gracefully without taking
any more medicines?
A: It took many years for women to accept
hormone replacement therapy. Estrogens are known to offer postmenopausal women
many physical benefits, improve their psychological well-being, and therefore
their overall quality of life, going full charge to the end.
- Q: am 72 years old. Am I too old to
start testosterone therapy?
A: No patient is too old to start
testosterone therapy if it is clearly indicated. As for any medication,
testosterone should be taken under a physician's care, with regular appropriate
follow-up evaluations.
- Q: Does having to take testosterone mean
I'm somehow less 'manly'?
A: Not at all. In fact, even the most "macho"
men can develop this condition.
- Q: Doesn't testosterone make men
aggressive and hostile?
A: Because of reports of the abuse of
anabolic steroids by athletes, testosterone has suffered a negative public
image. The perception is that testosterone is responsible for undesirable male
traits such as aggression and hyper-sexuality. And some people have developed a
fear that it will "bring out the beast in men". These, of course, are myths.
They stem from results of testosterone being used by men with normal
testosterone levels who took testosterone at doses which were much higher than
supplementation doses that are used in men going through Andropause.
- Q: I have been diagnosed with prostate
cancer. Can I take testosterone?
A: No. In men who have an existing cancer of
the prostate testosterone can promote its growth. This is why testosterone
replacement is not recommended for men with prostate cancer.
- Q: I have an enlarged prostate. Can I take
testosterone?
A: The prostate slowly enlarges as men age.
And in some men, testosterone can cause this process to speed up. However, in
most studies, no growth was found - even after long-term testosterone
replacement. Consequently, some men with enlarged prostates can qualify for
testosterone therapy, but others do not. Only a physician can make the decision
of whether you qualify. If you do take testosterone replacement your physician
will monitor the health of your prostate with regular (PSA) blood tests and
physical examinations.


Books Available
- Maximizing Manhood: Beating the Male Menopause
by Dr. Malcolm Carruthers, Thorsons
Publishing, Feb. 1998
- Understanding Men's Passages: Discovering the New
Map of Men's Lives by Gail Sheehy, Random House, April 1998
- The testosterone Solution: Increase your energy
and vigour with male hormone therapy, by Aubrey Hill, MD, Prima
Publishing, 1997
- Male Menopause: it's real and it's preventable.
Chapter 4 (Part 2) from the book Sex for Life, by David Saul, MD, Apple
Publishing Co Ltd., 1999
|